Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Biological ActivityMajor metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA.
Leung et al.
NorKA, the main metabolite of KA, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
Ebert et al.
Oral KA is antinociceptive in the rat formalin test: role of the metabolite, norKA.
Shimoyama et al.
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