Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki
= 3.6 μ
M for displacement of [3
H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo
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Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
Leung et al.
Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
Ebert et al.
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
Shimoyama et al.