Catalog Number: 1970
Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Biological Activity
Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.

R-enantiomer and S-enantiomer also available.

Technical Data
  • M.Wt:
    260.16
  • Formula:
    C12H14ClNO.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    79499-59-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Other Product-Specific Information:
R-enantiomer and S-enantiomer also available.
Background References
  1. Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
    Leung et al.
    J.Med.Chem., 1986;29:2396
  2. Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
    Ebert et al.
    Eur.J.Pharmacol., 1997;333:99
  3. Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
    Shimoyama et al.
    Pain, 1999;81:85

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