(S)-Norketamine hydrochloride

Key Product Details

Product Description

(S)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC₅₀ = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

R-enantiomer and racemate also available.

Product Specifications for (S)-Norketamine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-Norketamine hydrochloride

The following data is based on the product molecular weight 260.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.84 mL	19.22 mL	38.44 mL
5 mM	0.77 mL	3.84 mL	7.69 mL
10 mM	0.38 mL	1.92 mL	3.84 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID:  27096720
• Holtman Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 2008 PMID: 18586315

Product Documents for (S)-Norketamine hydrochloride