Catalog Number: 6112
Chemical Name: (S)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Biological Activity
NMDA receptor modulator. Metabolite of Ketamine hydrochloride (Cat. No.3131). Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models. R-enantiomer and racemate also available.
Technical Data
  • M.Wt:
    260.16
  • Formula:
    C12H14ClNO.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    83777-70-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
R-enantiomer and racemate also available.
Background References
  1. Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
    Singh et al.
    PLoS One, 2016;11:e0149499
  2. Effects of norketamine enantiomers in rodent models of persistent pain.
    Holtman et al.
    Pharmacol.Biochem.Behav., 2008;909:676
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