Group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1
receptors. Thought to act on a site separate from the glutamate binding pocket.
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Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Mabire et al.
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Lavreysen et al.
Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
van Wagenen et al.
Abstr.Soc.Neurosci., 2000;:Program No. 618.3.