NPS 2390

Catalog # Availability Size / Price Qty
4134/10
4134/50
Group I mGluR Antagonists Small Molecule
1 Image
Description: Group I mGlu antagonist

Chemical Name: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide

Purity: ≥99%

Product Details
Citations (1)
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Reviews

Biological Activity

Group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.

Technical Data

M.Wt:
307.39
Formula:
C19H21N3O
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
226878-01-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
    Mabire et al.
    J.Med.Chem., 2005;48:2134
  2. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Lavreysen et al.
    Mol.Pharmacol., 2003;63:1082
  3. Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
    van Wagenen et al.
    Abstr.Soc.Neurosci., 2000;:Program No. 618.3.

Product Datasheets

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Citation for NPS 2390

The citations listed below are publications that use Tocris products. Selected citations for NPS 2390 include:

1 Citation: Showing 1 - 1

  1. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor.
    Authors: Li Et al.
    Oxid Med Cell Longev  2016;2016:5203801

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