Chemical Name: N-tricyclo[18.104.22.168,7]dec-1-yl-2-quinoxalinecarboxamide
Biological ActivityGroup I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Mabire et al.
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Lavreysen et al.
Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
van Wagenen et al.
Abstr.Soc.Neurosci., 2000;:Program No. 618.3.
Citation for NPS 2390
The citations listed below are publications that use Tocris products. Selected citations for NPS 2390 include:
1 Citation: Showing 1 - 1
Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor.
Authors: Li Et al.
Oxid Med Cell Longev 2016;2016:5203801
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NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.