NPS 2390

Catalog # Availability Size / Price Qty
NPS 2390 | CAS No. 226878-01-9 | Group I mGluR Antagonists
1 Image
Description: Group I mGlu antagonist

Chemical Name: N-tricyclo[,7]dec-1-yl-2-quinoxalinecarboxamide

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products

Biological Activity

NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.

Technical Data

Soluble to 50 mM in DMSO and to 50 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
    Mabire et al.
    J.Med.Chem., 2005;48:2134
  2. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
    Lavreysen et al.
    Mol.Pharmacol., 2003;63:1082
  3. Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
    van Wagenen et al.
    Abstr.Soc.Neurosci., 2000;:Program No. 618.3.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for NPS 2390

The citations listed below are publications that use Tocris products. Selected citations for NPS 2390 include:

2 Citations: Showing 1 - 2


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NPS 2390

There are currently no reviews for this product. Be the first to review NPS 2390 and earn rewards!

Have you used NPS 2390?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.