Chemical Name: N-tricyclo[22.214.171.124,7]dec-1-yl-2-quinoxalinecarboxamide
Biological ActivityGroup I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Mabire et al.
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Lavreysen et al.
Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist.
van Wagenen et al.
Abstr.Soc.Neurosci., 2000;:Program No. 618.3.
Citation for NPS 2390
The citations listed below are publications that use Tocris products. Selected citations for NPS 2390 include:
1 Citation: Showing 1 - 1
Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor.
Authors: Li Et al.
Oxid Med Cell Longev 2016;2016:5203801
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for NPS 2390
Average Rating: 5 (Based on 1 Review)
Have you used NPS 2390?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.