NRX 252114

Key Product Details

Product Description

NRX-252114 is a potent enhancer of the interaction between S37A mutant β-catenin, and its cognate E3 ligase, SCF^β-TrCP (EC₅₀ = 6.5 nM; K_d = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on β-TrCP and induces mutant β-catenin ubiquitination and subsequent degradation.

Product Specifications for NRX 252114

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NRX 252114

The following data is based on the product molecular weight 510.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.96 mL	9.80 mL	19.60 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
10 mM	0.20 mL	0.98 mL	1.96 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Simonetta Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat.Commun. 2019 PMID: 30926793

Product Documents for NRX 252114