NS 11021

Biological Activity

Activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1). Exhibits no modulatory effect on a variety of K⁺ (K_V), Na⁺ and Ca²⁺ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BK_Ca in open and closed conformations; thought to bind the α subunit.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

1. BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
   Layne et al.
   Am.J.Physiol.Regul.Integr.Comp.Physiol., 2009;298:R378
2. The small molecule NS11021 is a potent and specific activator of Ca²⁺-activated big-conductance K⁺ channels.
   Bentzen et al.
   Mol.Pharmacol., 2007;72:1033
3. NS11021, a novel opener of large-conductance Ca²⁺-activated K⁺ channels, enhances erectile responses in rats.
   Kun et al.
   Br.J.Pharmacol., 2009;158:1465

Product Datasheets