Activator of large-conductance Ca2+
-activated potassium channels (BKCa
1.1). Exhibits no modulatory effect on a variety of K+
currents at concentrations <10 μ
M. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa
in open and closed conformations; thought to bind the α
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BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
Layne et al.
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen et al.
NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats.
Kun et al.