NS 11021

Tocris Bioscience | Catalog # 4788

KCa1.1 (BK) channel activator
Tocris Bioscience

Key Product Details

Description

KCa1.1 (BK) channel activator
View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Product Specifications for NS 11021

Molecular Weight

511.24

Formula

C16H9BrF6N6S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

CAS Number

956014-19-0

PubChem ID

24825677

InChI Key

MDKAFDIKYQMOMF-UHFFFAOYSA-N

SMILES

BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.12 100
Ethanol 51.12 100

Preparing Stock Solutions for NS 11021

The following data is based on the product molecular weight 511.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.56 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

Product Documents for NS 11021

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 11021

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for NS 11021 (2)

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  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Assay Type: In Vitro
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    NS 11021 4788
  • Great standard calcium activated potassium channel activator for K+ activation experiments
    Name: Farzana Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/06/2018
    NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.
    NS 11021 4788

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