NS 11021
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Biological Activity
Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
Layne et al.
Am.J.Physiol.Regul.Integr.Comp.Physiol., 2009;298:R378 -
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen et al.
Mol.Pharmacol., 2007;72:1033 -
NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats.
Kun et al.
Br.J.Pharmacol., 2009;158:1465
Product Datasheets
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Citation for NS 11021
The citations listed below are publications that use Tocris products. Selected citations for NS 11021 include:
1 Citation: Showing 1 - 1
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Molecular basis of ancestral vertebrate electroreception.
Authors: Bellono
Nature 2017;543:391
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The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.
