NS 11021

Catalog # Availability Size / Price Qty
4788/10
4788/50
Ca2+-Activated Potassium Channel Activators Small Molecule
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Description: Activator of BKCa (KCa1.1) channels

Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Technical Data

M.Wt:
511.24
Formula:
C16H9BrF6N6S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
956014-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NS 11021

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Great standard calcium activated potassium channel activator for K+ activation experiments
By Farzana Islam on 10/06/2018
Species: Human

NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.


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