Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Biological ActivityActivator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
Layne et al.
The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen et al.
NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats.
Kun et al.
Citation for NS 11021
The citations listed below are publications that use Tocris products. Selected citations for NS 11021 include:
1 Citation: Showing 1 - 1
Molecular basis of ancestral vertebrate electroreception.
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NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.