NS 11021

  ( 1 citations )    
Product Datasheet
Catalog Number:4788
Chemical Name:N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Product Details
Citations (1)
Reviews
Biological Activity
Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
Technical Data
  • M.Wt:
    511.24
  • Formula:
    C16H9BrF6N6S
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    956014-19-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NS 11021 include:

1 Citations: Showing 1 - 1

  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391

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