Catalog Number: 4788
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Biological Activity
Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.
    Layne et al.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2009;298:R378
  2. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
    Bentzen et al.
    Mol.Pharmacol., 2007;72:1033
  3. NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats.
    Kun et al.
    Br.J.Pharmacol., 2009;158:1465
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