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NS 11021

4788 1 Citation 2 Reviews Datasheet / COA / SDS
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NS 11021 | CAS No. 956014-19-0 | Ca2+-Activated Potassium Channel Activators
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Description: Activator of BKCa (KCa1.1) channels

Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

Purity: ≥98%

Product Details
Citations (1)
Reviews (2)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Technical Data

M.Wt:
511.24
Formula:
C16H9BrF6N6S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
956014-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for NS 11021

The citations listed below are publications that use Tocris products. Selected citations for NS 11021 include:

1 Citation: Showing 1 - 1

  1. Molecular basis of ancestral vertebrate electroreception.
    Authors: Bellono
    Nature  2017;543:391

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The pharmacological inhibitors for electrophysiology assay
By Anonymous on 02/28/2020
Application: Species: Other

The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.

PMID: 28264196
Great standard calcium activated potassium channel activator for K+ activation experiments
By Farzana Islam on 10/06/2018
Application: Species: Human

NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.

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