Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Biological ActivityNS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.
Olesen et al.
Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
Debska et al.
The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
Han et al.
Citation for NS 1619
The citations listed below are publications that use Tocris products. Selected citations for NS 1619 include:
1 Citation: Showing 1 - 1
BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation.
Authors: Khan Et al.
Sci Rep 2019;9:12285
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