Catalog Number: 3804
Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Biological Activity
Large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).
Technical Data
  • M.Wt:
    362.23
  • Formula:
    C15H8F6N2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    153587-01-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.
    Olesen et al.
    Eur.J.Pharmacol., 1994;251:53
  2. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
    Debska et al.
    Biochem.Pharmacol., 2003;65:1827
  3. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
    Han et al.
    Biochem.Biophys.Res.Comm., 2008;375:205

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