NS 1619

Tocris Bioscience | Catalog # 3804

KCa1.1 (BK) channel activator
Tocris Bioscience

Key Product Details

Description

KCa1.1 (BK) channel activator
View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Product Specifications for NS 1619

Molecular Weight

362.23

Formula

C15H8F6N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

CAS Number

153587-01-0

PubChem ID

4552

InChI Key

YLFMCMWKHSDUCT-UHFFFAOYSA-N

SMILES

O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.22 100
Ethanol 36.22 100

Preparing Stock Solutions for NS 1619

The following data is based on the product molecular weight 362.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.80 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for NS 1619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 1619

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for NS 1619 (2)

4.5 out of 5
2 Customer Ratings
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  • BK opening for the treatment of Pulmonary Hypertension
    Name: Sadequl Islam
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 09/13/2018
    NS1619 inhalation reduces RV pressure and improves oxygen supply and its application inhibits PASMC proliferation in vitro.
    The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.
  • Standard BK channel activator with great research potential
    Name: Farzana Islam
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 08/17/2018
    I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.
    NS 1619 3804

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