NS 1619

Catalog # Availability Size / Price Qty
3804/10
Ca2+-Activated Potassium Channel Activators Small Molecule
1 Image
Description: Activator of BKCa (KCa1.1) channels

Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Reviews (2)

Biological Activity

Large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Technical Data

M.Wt:
362.23
Formula:
C15H8F6N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
153587-01-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.
    Olesen et al.
    Eur.J.Pharmacol., 1994;251:53
  2. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
    Debska et al.
    Biochem.Pharmacol., 2003;65:1827
  3. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
    Han et al.
    Biochem.Biophys.Res.Comm., 2008;375:205

Product Datasheets

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BK opening for the treatment of Pulmonary Hypertension
By Sadequl Islam on 09/13/2018
Species: Rat

The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.


Standard BK channel activator with great research potential
By Farzana Islam on 08/17/2018
Species: Human

I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.


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