NS 1619

Catalog # Availability Size / Price Qty
NS 1619 | CAS No. 153587-01-0 | Ca2+-Activated Potassium Channel Activators
1 Image
Description: KCa1.1 (BK) channel activator

Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Citations (1)
Reviews (2)

Biological Activity

NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.
    Olesen et al.
    Eur.J.Pharmacol., 1994;251:53
  2. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
    Debska et al.
    Biochem.Pharmacol., 2003;65:1827
  3. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
    Han et al.
    Biochem.Biophys.Res.Comm., 2008;375:205

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for NS 1619

The citations listed below are publications that use Tocris products. Selected citations for NS 1619 include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NS 1619

Average Rating: 4.5 (Based on 2 Reviews)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used NS 1619?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

BK opening for the treatment of Pulmonary Hypertension
By Sadequl Islam on 09/13/2018
Application: Species: Rat

The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.

Standard BK channel activator with great research potential
By Farzana Islam on 08/17/2018
Application: Species: Human

I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.