NS 1619

Catalog # Availability Size / Price Qty
NS 1619 | CAS No. 153587-01-0 | Ca2+-Activated Potassium Channel Activators
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Description: KCa1.1 (BK) channel activator

Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.
    Olesen et al.
    Eur.J.Pharmacol., 1994;251:53
  2. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
    Debska et al.
    Biochem.Pharmacol., 2003;65:1827
  3. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
    Han et al.
    Biochem.Biophys.Res.Comm., 2008;375:205

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Citation for NS 1619

The citations listed below are publications that use Tocris products. Selected citations for NS 1619 include:

1 Citation: Showing 1 - 1


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