NS 19504

Catalog # Availability Size / Price Qty
5276/10
5276/50
Cat.No. 5276 - NS 19504 | C10H9BrN2S | CAS No. 327062-46-4
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Description: Activator of BKCa (KCa1.1) channels

Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazolamine

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

Technical Data

M.Wt:
269.16
Formula:
C10H9BrN2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
327062-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Used to study BK channel activation: Product worked nicely, would use again
By Sadequl Islam on 10/12/2018
Species: Mouse

The product is a BK channel opener and it performs well under channel opening conditions.In labs the product was stable, and did extremely well in experimental studies.


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