NS 19504

Tocris Bioscience | Catalog # 5276

KCa1.1 (BK) channel activator
Tocris Bioscience

Key Product Details

Description

KCa1.1 (BK) channel activator
View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

Product Specifications for NS 19504

Molecular Weight

269.16

Formula

C10H9BrN2S

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

5-[(4-Bromophenyl)methyl]-2-thiazolamine

CAS Number

327062-46-4

PubChem ID

727750

InChI Key

HGWLTZOMQZIUBW-UHFFFAOYSA-N

SMILES

NC1=NC=C(CC2=CC=C(Br)C=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.92 100
Ethanol 26.92 100

Preparing Stock Solutions for NS 19504

The following data is based on the product molecular weight 269.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.15 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for NS 19504

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 19504

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for NS 19504 (1)

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  • Used to study BK channel activation: Product worked nicely, would use again
    Name: Sadequl Islam
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 10/12/2018
    The product is a BK channel opener and it performs well under channel opening conditions.In labs the product was stable, and did extremely well in experimental studies.
    NS 19504 5276

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