Selective activator of large-conductance Ca2+
-activated potassium channels (BKCa
= 11 μ
M). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo
. Displays no effect on contractions induced by a high K+
concentration or at 65 other receptors tested, including L- and N- type Ca2+
and hERG channels.
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NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.
Nausch et al.