NS 398

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NS 398 | CAS No. 123653-11-2 | Cyclooxygenase Inhibitors
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Description: Cyclooxygenase-2 (COX-2) inhibitor

Chemical Name: N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide

Purity: ≥99%

Product Details
Citations (15)

Biological Activity

NS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NS 398

The citations listed below are publications that use Tocris products. Selected citations for NS 398 include:

15 Citations: Showing 1 - 10

  1. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
    Authors: Messerschmidt Et al.
    Mol Vis  2019;25:329
  2. Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide.
    Authors: Bonfill-Teixidor Et al.
    J Neuroinflammation  2017;14:3
  3. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
    Authors: Tunaru Et al.
    PLoS One  2016;12:e0163633
  4. Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor.
    Authors: Tunaru Et al.
    PLoS One  2016;11:e0163633
  5. Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat.
    Authors: Wei Et al.
    Hypertension  2015;65:1126
  6. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
    Authors: Ho Et al.
    J Virol  2015;22:46
  7. Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
    Authors: Liu Et al.
    Antioxid Redox Signal  2014;21:1571
  8. The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice.
    Authors: Sugiyama Et al.
    Osteoporos Int  2013;24:383
  9. Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
    Authors: Font-Nieves Et al.
    J Biol Chem  2012;287:6454
  10. Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.
    Authors: Buenestado Et al.
    Br J Pharmacol  2012;165:1877


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