Catalog Number: 0942
Chemical Name: N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Biological Activity
Selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.
Technical Data
  • M.Wt:
    314.36
  • Formula:
    C13H18N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    123653-11-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
    Elder et al.
    Int.J.Cancer, 2002;99:323
  2. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
    Futaki et al.
    Gen.Pharmacol., 1993;24:105
  3. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.
    Futaki et al.
    Prostaglandins, 1994;47:55
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NS 398 include:

10 Citations: Showing 1 - 10
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  1. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
    Authors: Tunaru Et al.
    PLoS One 2016;12:e0163633
  2. Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor.
    Authors: Tunaru Et al.
    PLoS One 2016;11:e0163633
  3. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
    Authors: Ho Et al.
    J Virol 2015;22:46
  4. The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice.
    Authors: Sugiyama Et al.
    Osteoporos Int 2013;24:383
  5. Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.
    Authors: Buenestado Et al.
    Br J Pharmacol 2012;165:1877
  6. Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance.
    Authors: Bourquin Et al.
    Cancer Res 2011;71:5123
  7. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
    Authors: Chia Et al.
    BMC Pharmacol 2011;11:10
  8. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Authors: Sunters Et al.
    J Biol Chem 2010;285:8743
  9. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res 2009;104:228
  10. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus.
    Authors: Ray Et al.
    PLoS One 2004;78:12964

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