Chemical Name: N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Biological ActivityNS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Elder et al.
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Futaki et al.
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.
Futaki et al.
Citations for NS 398
The citations listed below are publications that use Tocris products. Selected citations for NS 398 include:
15 Citations: Showing 1 - 10
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
Authors: Messerschmidt Et al.
Mol Vis 2019;25:329
Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide.
Authors: Bonfill-Teixidor Et al.
J Neuroinflammation 2017;14:3
Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
Authors: Tunaru Et al.
PLoS One 2016;12:e0163633
Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor.
Authors: Tunaru Et al.
PLoS One 2016;11:e0163633
Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat.
Authors: Wei Et al.
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Authors: Ho Et al.
J Virol 2015;22:46
Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Authors: Liu Et al.
Antioxid Redox Signal 2014;21:1571
The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice.
Authors: Sugiyama Et al.
Osteoporos Int 2013;24:383
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
Authors: Font-Nieves Et al.
J Biol Chem 2012;287:6454
Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.
Authors: Buenestado Et al.
Br J Pharmacol 2012;165:1877
Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance.
Authors: Bourquin Et al.
Cancer Res 2011;71:5123
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
Authors: Chia Et al.
BMC Pharmacol 2011;11:10
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
Authors: Sunters Et al.
J Biol Chem 2010;285:8743
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Authors: Wong Et al.
Circ Res 2009;104:228
Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus.
Authors: Ray Et al.
PLoS One 2004;78:12964
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