Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Biological ActivityNSC 319726 is a reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Allele-specific p53 mutant reactivation.
Yu et al.
Cancer Cell, 2012;21:614
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