Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175
mutant. Inhibits growth of fibroblasts expressing the p53R175
= 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175
mutation in vivo
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Allele-specific p53 mutant reactivation.
Yu et al.
Cancer Cell, 2012;21:614