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NSC 319726

Catalog #: 5065 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5065/10
5065/50
NSC 319726 | CAS No. 71555-25-4 | p53 Activators
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Description: Reactivator of mutant p53

Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

Purity: ≥98%

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Biological Activity

NSC 319726 is a reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.

Technical Data

M.Wt:
234.32
Formula:
C11H14N4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
71555-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Allele-specific p53 mutant reactivation.
    Yu et al.
    Cancer Cell, 2012;21:614

Product Datasheets

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