Chemical Name: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Biological ActivityReactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Allele-specific p53 mutant reactivation.
Yu et al.
Cancer Cell, 2012;21:614
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for NSC 319726
There are currently no reviews for this product. Be the first to review NSC 319726 and earn rewards!
Have you used NSC 319726?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image