Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
Biological ActivityNSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
Kubo et al.
Clin.Cancer Res., 1999;5:4279
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
McInnes et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for NSC 625987
There are currently no reviews for this product. Be the first to review NSC 625987 and earn rewards!
Have you used NSC 625987?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image