Catalog Number: 2152
Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
    Kubo et al.
    Clin.Cancer Res., 1999;5:4279
  2. Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
    McInnes et al.
    Chem.Biol., 2004;11:525
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