NSC 625987
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Description: Cdk4 inhibitor
Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
Purity: ≥98%
Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).Technical Data
M.Wt:
271.33
Formula:
C15H13NO2S
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
141992-47-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
Kubo et al.
Clin.Cancer Res., 1999;5:4279 -
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
McInnes et al.
Chem.Biol., 2004;11:525
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