Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Biological ActivityKDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.
Chu et al.
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Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.