NSC 636819

Tocris Bioscience | Catalog # 5287

KDM4A/KDM4B inhibitor
Tocris Bioscience

Key Product Details

Description

KDM4A/KDM4B inhibitor
View all Histone Demethylase Inhibitors »

Product Description

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

Product Specifications for NSC 636819

Molecular Weight

510.15

Formula

C22H12Cl4N2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene

CAS Number

1618672-71-1

PubChem ID

6288112

InChI Key

YYZPXBXVBQSBDG-IJIVKGSJSA-N

SMILES

ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.1 10

Preparing Stock Solutions for NSC 636819

The following data is based on the product molecular weight 510.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.60 mL 98.01 mL 196.02 mL
0.5 mM 3.92 mL 19.60 mL 39.20 mL
1 mM 1.96 mL 9.80 mL 19.60 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for NSC 636819

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NSC 636819

For research use only

Related Research Areas

Epigenetics

Customer Reviews for NSC 636819 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used NSC 636819?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card
Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Good Product.
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: Cancer Cell Lines
    Verified Customer | Posted 08/20/2018
    Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All