Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Biological ActivityKDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.
Chu et al.
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Used for inhibiting H3K9me3 demethylases on Pancreatic Cancer cell lines. works pretty well.