Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Biological ActivityCyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC50 = 1 uM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors.
Ortega et al.
3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity.
Monge et al.
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