Home / Cyclin-dependent Kinase Inhibitors / NSC 693868

NSC 693868

1937 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1937/10
1937/50
NSC 693868 | CAS No. 40254-90-8 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Cdk inhibitor; also inhibits GSK-3

Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amine

Purity: ≥99%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC50 = 1 uM).

Technical Data

M.Wt:
185.19
Formula:
C9H7N5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
40254-90-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
    Jorda et al.
    J.Med.Chem., 2018;61:9105
  2. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors.
    Ortega et al.
    Bioorg.Med.Chem.Lett., 2002;10:2177
  3. 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity.
    Monge et al.
    J.Heterocycl.Chem., 1995;31:1135

Product Datasheets

COA view current batch
or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NSC 693868

There are currently no reviews for this product. Be the first to review NSC 693868 and earn rewards!

Have you used NSC 693868?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.