Catalog Number: 1937
Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amine
Biological Activity
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
Technical Data
  • M.Wt:
    185.19
  • Formula:
    C9H7N5
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    40254-90-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors.
    Ortega et al.
    Bioorg.Med.Chem.Lett., 2002;10:2177
  2. 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity.
    Monge et al.
    J.Heterocycl.Chem., 1995;31:1135

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