NSC 693868

Key Product Details

Product Description

Cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC₅₀ = 1 _uM).

Product Specifications for NSC 693868

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 693868

The following data is based on the product molecular weight 185.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.40 mL	27.00 mL	54.00 mL
5 mM	1.08 mL	5.40 mL	10.80 mL
10 mM	0.54 mL	2.70 mL	5.40 mL
50 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Monge 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem.
• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Ortega Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 2002 PMID: 11983514

Product Documents for NSC 693868