Nutlin-3

Catalog # Availability Size / Price Qty
3984/10
3984/50
p53 Inhibitors Small Molecule
1 Image
Description: MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)

Biological Activity

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Technical Data

M.Wt:
581.49
Formula:
C30H30Cl2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
548472-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from F. Hoffmann-La Roche Ltd.

Background References

  1. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
    Vassilev et al.
    Science, 2004;303:844

Product Datasheets

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Citations for Nutlin-3

The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:

3 Citations: Showing 1 - 3

FAQs

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In vitro cell treatment using Nutlin (Cat. No. 3984)
By Anonymous on 01/08/2018
Species: Human

It worked perfectly at 10microM concentration for 48 hours.


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