Home / p53 Inhibitors / Nutlin-3

Nutlin-3

Catalog #: 3984
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3984/10
Nutlin-3 | CAS No. 548472-68-0 | p53 Inhibitors
1 Image
Description: MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Technical Data

M.Wt:
581.49
Formula:
C30H30Cl2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
548472-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from F. Hoffmann-La Roche Ltd.

Background References

  1. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
    Vassilev et al.
    Science, 2004;303:844

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Nutlin-3

The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:

3 Citations: Showing 1 - 3

  1. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
    Authors: Norlin Et al.
    Development  2018;145
  2. A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
    Authors: Yang Et al.
    Nat Commun  2016;7:13599
  3. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
    Authors: Bussey Et al.
    J Zhejiang Univ Sci B  2016;5:1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Nutlin 3a

6075
1 Image

Reviews for Nutlin-3

There are currently no reviews for this product. Be the first to review Nutlin-3 and earn rewards!

Have you used Nutlin-3?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.