Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Biological ActivityNutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev et al.
Citations for Nutlin-3
The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:
3 Citations: Showing 1 - 3
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Authors: Norlin Et al.
A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
Authors: Yang Et al.
Nat Commun 2016;7:13599
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
Authors: Bussey Et al.
J Zhejiang Univ Sci B 2016;5:1
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for Nutlin-3
Average Rating: 5 (Based on 1 Review)
Have you used Nutlin-3?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
It worked perfectly at 10microM concentration for 48 hours.