Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Biological ActivityMDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev et al.
Citations for Nutlin-3
The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:
3 Citations: Showing 1 - 3
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Authors: Norlin Et al.
A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
Authors: Yang Et al.
Nat Commun 2016;7:13599
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
Authors: Bussey Et al.
J Zhejiang Univ Sci B 2016;5:1
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Reviews for Nutlin-3
Average Rating: 5 (Based on 1 Review)
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It worked perfectly at 10microM concentration for 48 hours.