Nutlin-3

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3984
Chemical Name:(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Product Details
Citations (2)
Reviews
Biological Activity
MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Technical Data
  • M.Wt:
    581.49
  • Formula:
    C30H30Cl2N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    548472-68-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from F. Hoffmann-La Roche Ltd.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nutlin-3 include:

2 Citations: Showing 1 - 2
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  1. A redox mechanism underlying nucleolar stress sensing by nucleophosmin.
    Authors: Yang Et al.
    Nat Commun  2016;7:13599
  2. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
    Authors: Bussey Et al.
    J Zhejiang Univ Sci B  2016;5:1

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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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