Nutlin-3

Tocris Bioscience | Catalog # 3984

MDM2 antagonist; inhibits MDM2-p53 interaction
Tocris Bioscience

Key Product Details

Description

MDM2 antagonist; inhibits MDM2-p53 interaction
View all p53 Inhibitors »

Product Description

Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Licensing Information

Sold under license from F. Hoffmann-La Roche Ltd.

Product Specifications for Nutlin-3

Molecular Weight

581.49

Formula

C30H30Cl2N4O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

CAS Number

548472-68-0

PubChem ID

16755649

InChI Key

BDUHCSBCVGXTJM-IZLXSDGUSA-N

SMILES

ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.15 100
Ethanol 58.15 100

Preparing Stock Solutions for Nutlin-3

The following data is based on the product molecular weight 581.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.60 mL 17.20 mL
5 mM 0.34 mL 1.72 mL 3.44 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

Product Documents for Nutlin-3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nutlin-3

For research use only

Customer Reviews for Nutlin-3 (1)

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  • In vitro cell treatment using Nutlin (Cat. No. 3984)
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 01/08/2018
    It worked perfectly at 10microM concentration for 48 hours.

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