Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[188.8.131.52,7]decane-1-carboxamide
Biological ActivityNVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
Graf et al.
Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro.
Niwa et al.
Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.
Graf et al.
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