NVP 231

Catalog # Availability Size / Price Qty
3960/10
3960/50
NVP 231 | CAS No. 362003-83-6 | Other Kinase Inhibitors
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Description: Potent, selective and reversible CerK inhibitor

Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.

Technical Data

M.Wt:
431.55
Formula:
C25H25N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
362003-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
    Graf et al.
    Anal.Biochem., 2009;384:166
  2. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro.
    Niwa et al.
    Microvasc.Res., 2009;77:389
  3. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.
    Graf et al.
    Mol.Pharmacol., 2009;74:925

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