Catalog Number: 3960
Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[,7]decane-1-carboxamide
Biological Activity
Potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro.
    Niwa et al.
    Microvasc.Res., 2009;77:389
  2. A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
    Graf et al.
    Anal.Biochem., 2009;384:166
  3. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.
    Graf et al.
    Mol.Pharmacol., 2009;74:925
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