NVP 231

Key Product Details

Product Description

NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC₅₀ = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.

Product Specifications for NVP 231

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NVP 231

The following data is based on the product molecular weight 431.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.17 mL
5 mM	0.46 mL	2.32 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Niwa Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 2009 PMID: 19323974
• Graf Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 2009 PMID: 18612076
• Graf A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 2009 PMID: 18831956

Product Documents for NVP 231