NVP 2

Key Product Details

Product Description

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC₅₀ = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC₅₀ = 350 nM), displays <90% binding to CDK7 (IC₅₀ >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

Product Specifications for NVP 2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NVP 2

The following data is based on the product molecular weight 513.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Winter BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment. Mol.Cell 2017 PMID: 28673542
• Olson Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 2018 PMID: 29251720

Product Documents for NVP 2