Chemical Name: 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
Biological ActivityNVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Olson et al.
BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment.
Winter et al.
Citations for NVP 2
The citations listed below are publications that use Tocris products. Selected citations for NVP 2 include:
5 Citations: Showing 1 - 5
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
Authors: Jeffrey D Et al.
Cell Rep 2022;40:111106
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.
Authors: Brian Et al.
Cell Rep 2022;39:110970
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Authors: Johannes Et al.
Mol Cell 2021;81:830-844.e13
Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
Authors: Bernhard Et al.
Mol Cell 2020;77:1322-1339.e11
CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
Authors: Ignacio Et al.
Cell Rep 2020;33:108545
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