NVP-TNKS656

Tocris Bioscience | Catalog # 8913

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
Tocris Bioscience

Key Product Details

Description

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
View all Tankyrase Inhibitors »

Product Description

NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC50 values are 7.8 and 8.2 for TNKS1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.

Product Specifications for NVP-TNKS656

Molecular Weight

494.58

Formula

C27H34N4O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide

CAS Number

1419949-20-4

PubChem ID

136237316

InChI Key

DYGBNAYFDZEYBA-UHFFFAOYSA-N

SMILES

O=C1N=C(NC2=C1COCC2)CN(C(=O)CN3CCC(C(=O)C4=CC=C(OC)C=C4)CC3)CC5CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.95 10

Preparing Stock Solutions for NVP-TNKS656

The following data is based on the product molecular weight 494.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.22 mL 101.10 mL 202.19 mL
0.5 mM 4.04 mL 20.22 mL 40.44 mL
1 mM 2.02 mL 10.11 mL 20.22 mL
5 mM 0.40 mL 2.02 mL 4.04 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for NVP-TNKS656

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NVP-TNKS656

For research use only

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