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NVP-TNKS656

Catalog #: 8913 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8913/10
8913/50

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NVP-TNKS656 | CAS No. 1419949-20-4 | Tankyrase Inhibitors
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Description: Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells

Chemical Name: N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide

Purity: ≥98%

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Biological Activity

NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC50 values are 7.8 and 8.2 for TNSK1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.

Technical Data

M.Wt:
494.58
Formula:
C27H34N4O5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1419949-20-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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