NVS MLLT-1

Tocris Bioscience | Catalog # 7482

Selective MLLT1/3 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective MLLT1/3 inhibitor
View all Bromodomain Inhibitors »

Product Description

NVS MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3 (IC50 values are 150 and 254 nM for MLLT1 and MLLT3, respectively). It shows selectivity for YEATS2/4 domains and over all bromodomains (CERC2 IC50 > 40 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS MLLT-1 probe summary on the SGC website.

Product Specifications for NVS MLLT-1

Molecular Weight

385.47

Formula

C23H23N5O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide

CAS Number

2561471-13-2

PubChem ID

155925910

InChI Key

ZRTFTZCKJUNZIU-HNNXBMFYSA-N

SMILES

C[C@H]1CCCN1CC2=NC3=CC=C(C=C3N2)NC(C4=CC5=C(C=NC=C5)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.55 100
Ethanol 19.27 50

Preparing Stock Solutions for NVS MLLT-1

The following data is based on the product molecular weight 385.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.97 mL 25.94 mL
5 mM 0.52 mL 2.59 mL 5.19 mL
10 mM 0.26 mL 1.30 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NVS MLLT-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NVS MLLT-1

For research use only

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