NVS PAK1 1

Catalog # Availability Size / Price Qty
6132/25
6132/5
NVS PAK1 1 | CAS No. 1783816-74-9 | PAK Inhibitors
1 Image
Description: Potent and selective PAK1 inhibitor

Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

NVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM) that displays selective for PAK1 over PAK2 and a panel of 442 kinases. NVS PAK1 1 inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.

A negative control for NVS PAK1 1 is also available; NVS PAK1 C.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NVS-PAK1-1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
479.93
Formula:
C23H25ClF3N5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1783816-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS-PAK1-1 probe summary on the SGC website.

Background References

  1. Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor.
    Karpov et al.
    ACS Med.Chem.Lett, 2015;6:776

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NVS PAK1 C

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