NVS PAK1 1
Chemical Name: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
Biological ActivityNVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM) that displays selective for PAK1 over PAK2 and a panel of 442 kinases. NVS PAK1 1 inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.
A negative control for NVS PAK1 1 is also available; NVS PAK1 C.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NVS-PAK1-1 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor.
Karpov et al.
ACS Med.Chem.Lett, 2015;6:776
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