Obatoclax mesylate

Key Product Details

Product Description

Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC₅₀ values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.

Product Specifications for Obatoclax mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Obatoclax mesylate

The following data is based on the product molecular weight 413.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.84 mL	24.18 mL	48.37 mL
2.5 mM	0.97 mL	4.84 mL	9.67 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhai Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 2006 PMID: 16645636
• Nguyen Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 18040043

Product Documents for Obatoclax mesylate