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Okadaic acid ammonium salt

Name: Okadaic acid ammonium salt
Brand: Tocris Bioscience
SKU: 9012
Price: 379 USD
Availability: InStock

Tocris Bioscience | Catalog # 9012

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Product Documents

Protein phosphatase 1 and 2A inhibitor

Technical Data
Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Protein phosphatase 1 and 2A inhibitor

View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Okadaic acid ammonium salt is a potent inhibitor of protein phosphatase 1 (IC₅₀ = 3 nM) and protein phosphatase 2A (IC₅₀ = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Product Specifications for Okadaic acid ammonium salt

Molecular Weight

822.04

Formula

C₄₄H₆₇O₁₃.NH₄

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

9,10-Deepithio-9,10-didehydroacanthifolicin ammonium salt

CAS Number

175522-42-6

PubChem ID

162640608

InChI Key

ZBOMSHVRJSJGNR-GHIYGBLASA-N

SMILES

C[C@H]([C@H]1O[C@]2(OCCCC2)CC[C@H]1C)C[C@H](O)[C@@](C([C@H]3O)=C)([H])O[C@@](CC4)([H])[C@@]3([H])O[C@@]54CC[C@H](/C=C/[C@@H](C)[C@H](CC(C)=C6)O[C@@]76O[C@H](C[C@](O)(C)C([O-])=O)CC[C@H]7O)O5.[NH4+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Deng Molecular dynamic simulation on the synergistic corrosion inhibition effect and mechanism of quinoline quaternary ammonium salt and L-methionine. Chem.Technol.Fuels.Oils
Nuydens Okadaic acid-induced apopstosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998 PMID: 9489733
Haystead Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 1989 PMID: 2562908
McCluskey Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem 2002 PMID: 11881984
Cohen Okadaic acid: a new probe for the study of cellular regulation. TiBS 1990 PMID: 2158158

Product Documents for Okadaic acid ammonium salt

Certificate of Analysis

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Product Specific Notices for Okadaic acid ammonium salt

For research use only

Related Research Areas

Epigenetics

Phosphatases and Regulators

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