Catalog Number: 1641
Alternate Names: N-Oleoyldopamine
Chemical Name: (9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide
Biological Activity
Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anitallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates.
    Butelman et al.
    J.Pharmacol.Exp.Ther., 2004;311:155
  2. N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
    Chu et al.
    J.Biol.Chem., 2003;278:13633

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