Olopatadine hydrochloride

Key Product Details

Product Description

Olopatadine hydrochloride is a histamine H₁ receptor antagonist (K_i = 31.6 nM). Inhibits the release of histamine, prostaglandin D₂ and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Product Specifications for Olopatadine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Olopatadine hydrochloride

The following data is based on the product molecular weight 373.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.75 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Sharif Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharmacol.Exp.Ther. 1996 PMID: 8819509
• Tamura Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 2007 PMID: 17962722

Product Documents for Olopatadine hydrochloride