Catalog Number: 4241
Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Biological Activity
Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function.
    Tamura et al.
    Pharmacology, 2007;81:118
  2. Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases.
    Sharif et al.
    J.Pharm.Exp.Ther., 1996;278:1252
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