Catalog Number: 0934
Alternate Names: NE 19550
Chemical Name: N-Vanillyloleoylamide
Biological Activity
Potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interactions between synthetic vanilloids and the endogenous cannabinoid system.
    Di Marzo et al.
    FEBS Lett., 1998;436:449
  2. NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro.
    Dray et al.
    Eur.J.Pharmacol., 1990;181:289
  3. Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity.
    Janusz et al.
    J.Med.Chem., 1993;36:2595
  4. Cannabinoid activation of recombinant and endogenous vanilloid receptors.
    Ralevic et al.
    Eur.J.Pharmacol., 2001;424:211

The citations listed below are publications that use Tocris products. Selected citations for Olvanil include:

1 Citations: Showing 1 - 1

  1. Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.
    Authors: Witte Et al.
    Am J Physiol Endocrinol Metab 2002;7:466

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