Potent vanilloid receptor agonist (pEC50
values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50
= 9 μ
M) and may bind to CB1
cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Interactions between synthetic vanilloids and the endogenous cannabinoid system.
Di Marzo et al.
FEBS Lett., 1998;436:449
NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro.
Dray et al.
Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity.
Janusz et al.
Cannabinoid activation of recombinant and endogenous vanilloid receptors.
Ralevic et al.
The citations listed below are publications that use Tocris products. Selected citations for Olvanil include:
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