Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Biological ActivityOndansetron hydrochloride is a selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.
Youssefyeh et al.
Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders.
Ye et al.
CNS Drug Rev., 2001;7:199
Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice.
Ginawi et al.
Citations for Ondansetron hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:
5 Citations: Showing 1 - 5
Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats.
Authors: Spring Et al.
Low protein diets produce divergent effects on energy balance.
Authors: Pezeshki Et al.
PLoS One 2016;6:25145
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Authors: Amorim Et al.
Antioxid Redox Signal 2015;10:e0142919
Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.
Authors: Jin Et al.
Korean J Physiol Pharmacol 2014;18:149
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
Authors: Capasso Et al.
Br J Pharmacol 2012;165:1966
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