Catalog Number: 2891
Alternate Names: GR 38032
Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Biological Activity
Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
Technical Data
  • M.Wt:
    329.83
  • Formula:
    C18H19N3O.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    99614-01-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.
    Youssefyeh et al.
    J.Med.Chem., 1992;35:895
  2. Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders.
    Ye et al.
    CNS Drug Rev., 2001;7:199
  3. Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice.
    Ginawi et al.
    Pharmacol.Res., 2005;51:255
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Low protein diets produce divergent effects on energy balance.
    Authors: Pezeshki Et al.
    PLoS One 2016;6:25145
  2. Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
    Authors: Amorim Et al.
    Antioxid Redox Signal 2015;10:e0142919

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