Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Biological ActivityOndansetron hydrochloride is a selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC50 = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC50 = 0.1 nM) in human recombinant h5-HT3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.
Youssefyeh et al.
Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders.
Ye et al.
CNS Drug Rev., 2001;7:199
Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice.
Ginawi et al.
Citations for Ondansetron hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:
5 Citations: Showing 1 - 5
Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats.
Authors: Spring Et al.
Low protein diets produce divergent effects on energy balance.
Authors: Pezeshki Et al.
PLoS One 2016;6:25145
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Authors: Amorim Et al.
Antioxid Redox Signal 2015;10:e0142919
Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons.
Authors: Jin Et al.
Korean J Physiol Pharmacol 2014;18:149
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
Authors: Capasso Et al.
Br J Pharmacol 2012;165:1966
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