Nonpeptide vasopressin V1
receptor antagonist. Displays greater affinity for rat V1
than human V1
values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1
receptors over V2
receptors. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans.
Imaizumi et al.
A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor.
Thibonnier et al.
OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.
Yamamura et al.