Catalog Number: 3924
Chemical Name: N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide
Biological Activity
Nonpeptide vasopressin V1 receptor antagonist. Displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1 receptors over V2 receptors. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans.
    Imaizumi et al.
    Hypertension, 1992;20:54
  2. A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor.
    Thibonnier et al.
    J.Pharmacol.Exp.Ther., 2000;294:195
  3. OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.
    Yamamura et al.
    Science, 1991;252:572

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