OPC 21268

Key Product Details

Product Description

OPC 21268 is a nonpeptide vasopressin V₁ receptor antagonist. Displays greater affinity for rat V₁ than human V₁ (K_i values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V₁ receptors over V₂ receptors. Orally active.

Product Specifications for OPC 21268

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OPC 21268

The following data is based on the product molecular weight 449.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.12 mL	22.24 mL
5 mM	0.44 mL	2.22 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Imaizumi Effects of OPC-21268, an orally effective vasopressin V₁ receptor antagonist in humans. Hypertension 1992 PMID: 1319959
• Thibonnier A molecular model of agonist and nonpeptide antagonist binding to the human V₁ vascular vasopressin receptor. J.Pharmacol.Exp.Ther. 2000 PMID: 10871312
• Yamamura OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 1991 PMID: 1850553

Product Documents for OPC 21268