OR-486

Key Product Details

Product Description

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

Product Specifications for OR-486

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OR-486

The following data is based on the product molecular weight 200.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

8 7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.00 mL	24.99 mL	49.97 mL
5 mM	1.00 mL	5.00 mL	9.99 mL
10 mM	0.50 mL	2.50 mL	5.00 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Borgulya Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta
• Mannisto and Kaakola Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 1990 PMID: 2196554

Product Documents for OR-486