Endogenous agonist at orexin receptors (Ki
values are 420 and 36 nM for OX1
receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.
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All Tocris products are intended for laboratory research use only.
The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
Kilduff and Peyron
Orexins: a new family of neuropeptides.
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
Sakurai et al.
The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.
Guerreiro et al.
The citations listed below are publications that use Tocris products. Selected citations for Orexin B (human) include:
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