Catalog Number: 1456
Biological Activity
Endogenous agonist at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.
Technical Data
  • M.Wt:
    2899.36
  • Formula:
    C123H212N44O35S
  • Sequence:
    RSGPPGLQGRLQRLLQASGNHAAGILTM

    (Modifications: Met-28 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    205640-91-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
    Kilduff and Peyron
    TiNS, 2000;23:359
  2. Orexins: a new family of neuropeptides.
    Smart
    Br.J.Anaesth., 1999;83:695
  3. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
    Sakurai et al.
    Cell, 1998;92:573
  4. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.
    Guerreiro et al.
    Mol.Pharmacol., 2015;87:525
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Orexin B (human) include:

2 Citations: Showing 1 - 2
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  1. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.
    Authors: Guerreiro Et al.
    Mol.Pharmacol. 2015;87:525
  2. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
    Authors: Malherbe Et al.
    Br.J.Pharmacol. 2009;156:1326

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