Catalog Number: 1457
Biological Activity
Endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions.
Technical Data
  • M.Wt:
    2936.43
  • Formula:
    C126H215N45O34S
  • Sequence:
    RPGPPGLQGRLQRLLQANGNHAAGILTM

    (Modifications: Met-28 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    202801-92-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
    Kilduff and Peyron
    TiNS, 2000;23:359
  2. Orexins: a new family of neuropeptides.
    Smart
    Br.J.Anaesth., 1999;83:695
  3. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
    Sakurai et al.
    Cell, 1998;92:573
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Orexin B (mouse) include:

2 Citations: Showing 1 - 2
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  1. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res 2012;318:2004
  2. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
    Authors: Holland Et al.
    J Biol Chem 2005;315:1380

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