Org 20599

Tocris Bioscience | Catalog # 2738

Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
Tocris Bioscience
Discontinued Product
2738 has been discontinued. View all GABA-A Receptor Modulators products.

Key Product Details

Description

Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
View all GABA-A Receptor Modulators »

Product Description

Org 20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Product Specifications for Org 20599

Molecular Weight

438.04

Formula

C25H40ClNO3

Storage

Store at RT

Chemical Name

(2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one

CAS Number

156685-94-8

PubChem ID

9850026

InChI Key

NZFNABGZEQPYBX-PMBZPZLSSA-N

SMILES

O=[C@](CCl)[C@H]4CC[C@@]3([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 43.8 100
DMSO 43.8 100

Preparing Stock Solutions for Org 20599

The following data is based on the product molecular weight 438.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.41 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Org 20599

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Org 20599

For research use only

Related Research Areas

GABA Receptors

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