Positive allosteric modulator and at higher concentrations direct agonist of GABAA
= 1.1 μ
M). Also displays positive modulation of glycine receptors (EC50
= 22.9 μ
M). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
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All Tocris products are intended for laboratory research use only.
Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo.
Visser et al.
The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors.
Weir et al.
The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599.
Hill-Venning et al.