Catalog Number: 2738
Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one
Biological Activity
Positive allosteric modulator and at higher concentrations direct agonist of GABAA receptors (EC50 = 1.1 μM). Also displays positive modulation of glycine receptors (EC50 = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo.
    Visser et al.
    J.Pharmacol.Exp.Ther., 2002;303:616
  2. The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors.
    Weir et al.
    Br.J.Anaesth., 2004;92:704
  3. The anaesthetic action and modulaton of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599.
    Hill-Venning et al.
    Neuropharmacology, 1996;35:1209
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