Ortho AP 1867

Key Product Details

Product Description

Ortho AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V. Functionalized with a carboxylic acid group in the ortho-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability. Ortho AP 1867 is a precursor for the dTAG compounds.

Product Specifications for Ortho AP 1867

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ortho AP 1867

The following data is based on the product molecular weight 693.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585

Product Documents for Ortho AP 1867