Oseltamivir phosphate

Key Product Details

Product Description

Oseltamivir phosphate is a viral neuraminidase inhibitor prodrug; metabolized to GS 4071. Metabolite exhibits potent inhibition of neuraminidase from multiple influenza strains (IC₅₀ values range from 0.3 to 2 nM). Inhibits cellular effects of influenza infection in vitro (IC₅₀ values range from 0.6 to 150 nM). Displays highest potency against H1N1 and H3N2 influenza A strains. Inhibits H1N1 influenza infection in mice.

Product Specifications for Oseltamivir phosphate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Oseltamivir phosphate

The following data is based on the product molecular weight 410.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mendel Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob.Agents Chemother. 1998 PMID: 9517945
• Kim Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J.Am.Chem.Soc. 1997 PMID: 16526129

Product Documents for Oseltamivir phosphate