OTX 015

Catalog # Availability Size / Price Qty
6181/10
6181/50
OTX 015 | CAS No. 202590-98-5 | Bromodomain Inhibitors
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Description: BET bromodomain inhibitor; orally bioavailable
Alternative Names: Birabresib

Chemical Name: (6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Purity: ≥98%

Product Details
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Biological Activity

OTX 015 is a BET bromodomain inhibitor (IC50 values are in the range 92 - 112 nM). Inhibits proliferation and induces apoptosis of leukemia cell lines in vitro. Decreases BRD2, BRD4 and c-MYC protein expression. Orally bioavailable.

Technical Data

M.Wt:
491.99
Formula:
C25H22ClN5O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
202590-98-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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