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OX 04528

Catalog #: 8131 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8131/10
8131/50

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OX 04528 | CAS No. 3028055-45-7 | Orphan 7-TM Receptor Agonists
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Description: Highly potent and selective GPR84 agonist

Chemical Name: 3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine-1-oxide

Purity: ≥98%

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Biological Activity

OX 04528 is a highly potent and selective GPR84 agonist. It inhibits cAMP production in CHO cells expressing human GPR84 (EC50 = 6 pM) and shows no β-arrestin recruitment. Exhibits selectivity for GPR84 over FFA1, FFA4, and CB2 receptors. In vivo, OX 04528 shows a half-life of 58 minutes following oral dosing at 10 mg/kg in mouse pharmacokinetic studies. OX 04528 is orally bioavailable.

Technical Data

M.Wt:
365.28
Formula:
C16H13F6NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3028055-45-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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