OX 04528

Key Product Details

Product Description

OX 04528 is a highly potent and selective GPR84 agonist. It inhibits cAMP production in CHO cells expressing human GPR84 (EC₅₀ = 6 pM) and shows no β-arrestin recruitment. Exhibits selectivity for GPR84 over FFA1, FFA4, and CB2 receptors. In vivo, OX 04528 shows a half-life of 58 minutes following oral dosing at 10 mg/kg in mouse pharmacokinetic studies. OX 04528 is orally bioavailable.

Product Specifications for OX 04528

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OX 04528

The following data is based on the product molecular weight 365.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.69 mL	27.38 mL
5 mM	0.55 mL	2.74 mL	5.48 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Development of highly potent, G-protein pathway biased, selective, and orally bioavailable GPR84 agonists. J.Med.Chem. 2024 PMID: 38146625

Product Documents for OX 04528