OXSI 2
Chemical Name: 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
Purity: ≥98%
Biological Activity
OXSI 2 is a potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Lai et al.
Bioorg.Med.Chem.Lett., 2003;13:3111 -
The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux.
Yaron et al.
Biochem.Biophys.Res.Commun., 2016;472:545
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for OXSI 2
There are currently no reviews for this product. Be the first to review OXSI 2 and earn rewards!
Have you used OXSI 2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
