OXSI 2

Key Product Details

Product Description

OXSI 2 is a potent Syk kinase inhibitor (IC₅₀ = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.

Product Specifications for OXSI 2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OXSI 2

The following data is based on the product molecular weight 353.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yaron The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 2016 PMID: 26970308
• Lai Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 2003 PMID: 12941345

Product Documents for OXSI 2