Nigericin sodium salt

  ( 3 citations )    
Product Datasheet
Catalog Number:4312
Chemical Name:(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4
Product Details
Citations (3)
Reviews
Biological Activity
Potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
Technical Data
  • M.Wt:
    746.94
  • Formula:
    C40H67NaO11
  • Solubility:
    Soluble to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    28643-80-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nigericin sodium salt include:

3 Citations: Showing 1 - 3
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  1. Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.
    Authors: Ahn Et al.
    Sci Rep  2017;7:1314
  2. Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation.
    Authors: Ahn Et al.
    Sci Rep  2017;7:12409
  3. Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome
    Authors: Lee Et al.
    Cellular Immunology  2016;306-307:53

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