Nigericin sodium salt

Tocris Bioscience | Catalog # 4312

Selective K+ ionophore
Tocris Bioscience

Key Product Details

Description

Selective K+ ionophore
View all Ionophores »

Product Description

Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Product Specifications for Nigericin sodium salt

Molecular Weight

746.94

Formula

C40H67NaO11

Storage

Store at -20°C

Chemical Name

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt

CAS Number

28643-80-3

PubChem ID

16760591

InChI Key

MOYOTUKECQMGHE-PDEFJWSRSA-M

SMILES

[Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 74.69 100

Preparing Stock Solutions for Nigericin sodium salt

The following data is based on the product molecular weight 746.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.69 mL 13.39 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 41 publications citing the usage of this product.

Product Documents for Nigericin sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Nigericin sodium salt

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Nigericin sodium salt

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