Catalog Number: 4312
Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4
Biological Activity
Potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
Technical Data
  • M.Wt:
    746.94
  • Formula:
    C40H67NaO11
  • Solubility:
    Soluble to 100 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    28643-80-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin.
    Hamidinia et al.
    Biochemistry., 2004;43:15956
  2. Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles.
    Eytan et al.
    J.Biol.Chem., 1990;22:12949
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nigericin sodium salt include:

1 Citations: Showing 1 - 1

  1. Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome
    Authors: Lee Et al.
    Cellular Immunology 2016;306-307:53

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