Nigericin sodium salt

Catalog # Availability Size / Price Qty
4312/10
Nigericin sodium salt | CAS No. 28643-80-3 | Ionophores
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Description: Selective K+ ionophore

Chemical Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt

Product Details
Citations (7)
Reviews

Biological Activity

Potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data

M.Wt:
746.94
Formula:
C40H67NaO11
Solubility:
Soluble to 100 mM in ethanol
Storage:
Store at -20°C
CAS No:
28643-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin.
    Hamidinia et al.
    Biochemistry., 2004;43:15956
  2. Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles.
    Eytan et al.
    J.Biol.Chem., 1990;22:12949

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Citations for Nigericin sodium salt

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