P 22077

Catalog # Availability Size / Price Qty
4485/10
4485/50
P 22077 | CAS No. 1247819-59-5 | Deubiquitinating Enzyme Inhibitors
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Description: USP7 inhibitor

Chemical Name: 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone

Purity: ≥99%

Product Details
Citations (3)
Reviews (2)

Biological Activity

Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

Technical Data

M.Wt:
315.32
Formula:
C12H7F2NO3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1247819-59-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for P 22077

The citations listed below are publications that use Tocris products. Selected citations for P 22077 include:

3 Citations: Showing 1 - 3

  1. USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
    Authors: Ji Et al.
    Nat Commun  2019;10:4184
  2. USP7 is a SUMO deubiquitinase essential for DNA replication.
    Authors: Lecona Et al.
    Nat Struct Mol Biol  2016;23:270
  3. USP7 cooperates with SCML2 to regulate the activity of PRC1.
    Authors: Lecona Et al.
    Pharmacol Res Perspect  2015;35:1157

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P22077 was seen to induce tumor cell death
By Anonymous on 12/14/2019
Application: Species: Human

P22077 was seen to induce (tumor) cell death with EC50 values in the low micromolar range. P22077 inhibition exhibited changes in ubiquitylated protein levels that are distinct from the broad specificity inhibitor.


USP7 inhibitors 2 (P22077)
By Anonymous on 12/10/2019
Application: Species: Human

HEK293T cells stably expressing the STF-Luc reporter were pretreated with increasing amounts of USP7 inhibitors P22077

PMID: 31519875

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