P 22077

  ( 2 citations )    
Product Datasheet
Catalog Number:4485
Chemical Name:1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone
Product Details
Citations (2)
Reviews
Biological Activity
Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.
Technical Data
  • M.Wt:
    315.32
  • Formula:
    C12H7F2NO3S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1247819-59-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for P 22077 include:

2 Citations: Showing 1 - 2
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  1. USP7 is a SUMO deubiquitinase essential for DNA replication.
    Authors: Lecona Et al.
    Nat Struct Mol Biol  2016;23:270
  2. USP7 cooperates with SCML2 to regulate the activity of PRC1.
    Authors: Lecona Et al.
    Pharmacol Res Perspect  2015;35:1157

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