Inhibitor of ubiquitin-specific protease (USP) 7 (EC
M); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin
. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.
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All Tocris products are intended for laboratory research use only.
Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers.
Loch et al.
Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.
Tian et al.
Assay Drug Dev.Technol., 2011;9:165
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Dar et al.
Mol.Cell Biol., 2013;33:3309
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