Inhibitor of ubiquitin-specific protease (USP) 7 (EC50
= 8.6 μ
M); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro
. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.
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Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers.
Loch et al.
Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.
Tian et al.
Assay Drug Dev.Technol., 2011;9:165
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Dar et al.
Mol.Cell Biol., 2013;33:3309
The citations listed below are publications that use Tocris products. Selected citations for P 22077 include:
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