P 22077

Catalog # Availability Size / Price Qty
P 22077 | CAS No. 1247819-59-5 | Deubiquitinating Enzyme Inhibitors
1 Image
Description: USP7 inhibitor

Chemical Name: 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone

Purity: ≥99%

Product Details
Citations (3)

Biological Activity

P 22077 is an inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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Citations for P 22077

The citations listed below are publications that use Tocris products. Selected citations for P 22077 include:

3 Citations: Showing 1 - 3

  1. USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
    Authors: Ji Et al.
    Nat Commun  2019;10:4184
  2. USP7 is a SUMO deubiquitinase essential for DNA replication.
    Authors: Lecona Et al.
    Nat Struct Mol Biol  2016;23:270
  3. USP7 cooperates with SCML2 to regulate the activity of PRC1.
    Authors: Lecona Et al.
    Pharmacol Res Perspect  2015;35:1157


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