P1
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity: ≥98%
Biological Activity
P1 is a protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase
Ge et al.
ACS Chem.Biol., 2013;8:2577 -
Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.
Xu et al.
PLoS One, 2013;8:e76657
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