Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Biological ActivityProtein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase
Ge et al.
ACS Chem.Biol., 2013;8:2577
Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.
Xu et al.
PLoS One, 2013;8:e76657
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