Photoswitchable epithelial sodium channel (ENaC) blocker (IC50
values are 90 and 390 nM for αβγ
ENaCs, respectively, in the trans
conformation). Switches conformation from cis
at 500 nm and trans
at 400 nm. Blocks ENaCs with greater efficacy in the cis
conformation, in comparison to the trans
conformation, in Xenopus
oocytes and HEK293t cells. Partially blocks δβγ
ENaCs in the trans
conformation and exhibits near maximal block of δβγ
ENaCs in the cis
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Controlling epithelial sodium channels with light using photoswitchable amilorides.
Schönberger et al.