PA 1 dihydrochloride

Catalog # Availability Size / Price Qty
5463/10
5463/50
Cat.No. 5463 - PA 1 dihydrochloride | C18H16ClN9O.2HCl
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Description: Photoswitchable ENaC blocker

Chemical Name: 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride

Product Details
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Biological Activity

Photoswitchable epithelial sodium channel (ENaC) blocker (IC50 values are 90 and 390 nM for αβγ and δβγENaCs, respectively, in the trans conformation). Switches conformation from cis to trans at 500 nm and trans to cis at 400 nm. Blocks ENaCs with greater efficacy in the cis conformation, in comparison to the trans conformation, in Xenopus oocytes and HEK293t cells. Partially blocks δβγENaCs in the trans conformation and exhibits near maximal block of δβγENaCs in the cis conformation. Amiloride derivative.

Technical Data

Formula:
C18H16ClN9O.2HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Controlling epithelial sodium channels with light using photoswitchable amilorides.
    Schönberger et al.
    Nat.Chem., 2014;6:712

Product Datasheets

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