PA 1 dihydrochloride

Key Product Details

Product Description

Photoswitchable epithelial sodium channel (ENaC) blocker (IC₅₀ values are 90 and 390 nM for αβγ and δβγENaCs, respectively, in the trans conformation). Switches conformation from cis to trans at 500 nm and trans to cis at 400 nm. Blocks ENaCs with greater efficacy in the cis conformation, in comparison to the trans conformation, in Xenopus oocytes and HEK293t cells. Partially blocks δβγENaCs in the trans conformation and exhibits near maximal block of δβγENaCs in the cis conformation. Amiloride derivative.

Product Specifications for PA 1 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PA 1 dihydrochloride

The following data is based on the product molecular weight 482.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.71 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schönberger Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat.Chem. 2014 PMID: 25054942

Product Documents for PA 1 dihydrochloride