Catalog Number: 1186
Alternate Names: Pituitary Adenylate Cyclase-Activating Polypeptide 1-38
Biological Activity
Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase.
Technical Data
  • M.Wt:
    4535
  • Formula:
    C203H331N63O53S
  • Sequence:
    HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK

    (Modifications: Lys-38 = C-terminal amide)

  • Solubility:
    Soluble to 0.90 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    137061-48-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor
    Lazarovici et al.
    Mol.Pharmacol., 1998;54:547
  2. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
    Michel et al.
    Pharmacol.Rev., 1998;50:143
  3. Pituitary adenylate cyclase-activating polypeptide increase [Ca2+]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism.
    Rawlings et al.
    J.Biol.Chem., 1994;269:5680
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PACAP 1-38 include:

2 Citations: Showing 1 - 2
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  1. Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.
    Authors: Sakamoto Et al.
    J Diabetes Res 2015;2015:727152
  2. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    J Cereb Blood Flow Metab 2012;215:291

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