Palonosetron hydrochloride

Key Product Details

Product Description

Palonosetron hydrochloride is a highly potent and high affinity 5-HT₃ antagonist (IC₅₀ = 0.24 nM for 5-HT_3A; pK_i = 10.4). Displays a slow dissociation rate. Inhibits 5-HT-induced enhancement of cellular response to substance P (Cat. No. 1156) in vitro. Inhibits cisplatin (Cat. No. 2251)-induced enhancement of substance P response in vivo.

Product Specifications for Palonosetron hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Palonosetron hydrochloride

The following data is based on the product molecular weight 332.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	15.02 mL	30.04 mL
5 mM	0.60 mL	3.00 mL	6.01 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Del Cadia Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg.Med.Chem. 2013 PMID: 24128813
• Rojas The antiemetic 5-HT₃ receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 2010 PMID: 20724484
• Lummis & Thompson Agonists and antagonists induce different palonosetron dissociation rates in 5-HT_3A and 5-HT_3AB receptors. Neuropharmacology. 2013 PMID: 23747573
• Wong The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT₃ receptors, in vitro. Br.J.Pharmacol. 1995 PMID: 7773546

Product Documents for Palonosetron hydrochloride