Pamoic acid disodium salt

Key Product Details

Product Description

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC₅₀ values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Product Specifications for Pamoic acid disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pamoic acid disodium salt

The following data is based on the product molecular weight 432.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.57 mL	23.13 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jenkins Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 2012 PMID: 22967846
• Zhao Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 2010 PMID: 20826425

Product Documents for Pamoic acid disodium salt