Catalog Number: 4298
Chemical Name: 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt
Biological Activity
GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
    Zhao et al.
    Mol.Pharmacol., 2010;78:560
  2. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
    Jenkins et al.
    J.Pharmacol.Exp.Ther., 2012;343:683
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