Pamoic acid disodium salt
Chemical Name: 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt
Biological ActivityGPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
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Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
Jenkins et al.
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
Zhao et al.
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