GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50
values are 22 and 65 nM respectively). Mediates recruitment of β
-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
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Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
Zhao et al.
Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.
Jenkins et al.