Catalog Number: 2141
Chemical Name: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Biological Activity
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
Technical Data
  • M.Wt:
    445.44
  • Formula:
    C19H20FNO3.C4H4O4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    64006-44-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
    Owens et al.
    J.Pharmacol.Exp.Ther., 1997;283:1305
  2. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor.
    Thomas et al.
    Psychopharmacology, 1987;93:193
  3. Paroxetine: a review.
    Bourin et al.
    CNS Drug Rev., 2001;7:25
  4. Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine.
    Fujishiro et al.
    Eur.J.Pharmacol., 2002;454:183
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Paroxetine maleate include:

2 Citations: Showing 1 - 2
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  1. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection.
    Authors: Steiner Et al.
    J Neurosci 2015;12:200
  2. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
    Authors: Huang Et al.
    BMC Neurosci 2009;29:13909

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