Paroxetine maleate

  ( 5 citations )    
Product Datasheet
Catalog Number:2141
Chemical Name:(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Product Details
Citations (5)
Reviews
Biological Activity
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
Technical Data
  • M.Wt:
    445.44
  • Formula:
    C19H20FNO3.C4H4O4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    64006-44-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Paroxetine maleate include:

5 Citations: Showing 1 - 5
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  1. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection.
    Authors: Steiner Et al.
    J Neurosci  2015;12:200
  2. Systemic modulation of serotonergic synapses via reuptake blockade or 5HT1A receptor antagonism does not alter perithreshold taste sensitivity in rats.
    Authors: Mathes and Spector
    Chem Senses  2014;39:583
  3. The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions.
    Authors: Mathes Et al.
    Chem Senses  2013;38:211
  4. The selective serotonin reuptake inhibitor paroxetine does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats.
    Authors: Mathes and Spector
    Chem Senses  2011;36:515
  5. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
    Authors: Huang Et al.
    BMC Neurosci  2009;29:13909

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