Chemical Name: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Biological ActivityParoxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor.
Thomas et al.
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
Owens et al.
Paroxetine: a review.
Bourin et al.
CNS Drug Rev., 2001;7:25
Comparison of the anticholin. effects of the serotonergic antidepressants, paroxetine, fluvox. and clomipramine.
Fujishiro et al.
Citations for Paroxetine maleate
The citations listed below are publications that use Tocris products. Selected citations for Paroxetine maleate include:
7 Citations: Showing 1 - 7
A neural circuit for comorbid depressive symptoms in chronic pain.
Authors: Zhou Et al.
Nat Neurosci 2019;22:1649
Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.
Authors: Lazar Et al.
Front Pharmacol 2015;6:210
Interaction of parox. with mitochondrial proteins mediates neuroprotection.
Authors: Steiner Et al.
J Neurosci 2015;12:200
Systemic modulation of serotonergic synapses via reuptake blockade or 5HT1A receptor antagonism does not alter perithreshold taste sensitivity in rats.
Authors: Mathes and Spector
Chem Senses 2014;39:583
The selective serotonin reuptake inhibitor parox. decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and qine solutions.
Authors: Mathes Et al.
Chem Senses 2013;38:211
The selective serotonin reuptake inhibitor parox. does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats.
Authors: Mathes and Spector
Chem Senses 2011;36:515
Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
Authors: Huang Et al.
BMC Neurosci 2009;29:13909
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