PARPi-FL

Catalog # Availability Size / Price Qty
6461/1
Cat.No. 6461 - PARPi-FL | C34H32BF3N6O3 | CAS No. 1380359-84-1
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Description: Potent fluorescent PARP inhibitor; cell permeable

Chemical Name: (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron

Purity: ≥95%

Product Details
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Biological Activity

Fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.

Technical Data

M.Wt:
640.46
Formula:
C34H32BF3N6O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1380359-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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