PARPi-FL

Tocris Bioscience | Catalog # 6461

Potent fluorescent PARP inhibitor; cell permeable
Tocris Bioscience

Key Product Details

Description

Potent fluorescent PARP inhibitor; cell permeable

Alternative Names

AZD2281-BDY FL,Olaparib-BDY FL

Wavelength

Excitation = 502 nm, Emission = 510 nm
View all Poly(ADP-ribose) Polymerase Inhibitors »

Product Description

PARPi-FL is a fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.

Optical Data

Emission Color Green
λabs 502 nm
λem 510 nm

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Product Specifications for PARPi-FL

Molecular Weight

640.46

Formula

C34H32BF3N6O3

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron

CAS Number

1380359-84-1

PubChem ID

70697686

InChI Key

IGUTVNUEFKPBGK-UHFFFAOYSA-N

SMILES

CC1=CC(C)=[N+]2C1=CC3=CC=C(N3[B-]2(F)F)CCC(N4CCN(C(C5=CC(CC6=NNC(C7=CC=CC=C67)=O)=CC=C5F)=O)CC4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.4 10

Preparing Stock Solutions for PARPi-FL

The following data is based on the product molecular weight 640.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.61 mL 78.07 mL 156.14 mL
0.5 mM 3.12 mL 15.61 mL 31.23 mL
1 mM 1.56 mL 7.81 mL 15.61 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for PARPi-FL

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PARPi-FL

For research use only

Related Research Areas

Apoptosis

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