PARPi-FL

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6461/1

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PARPi-FL | CAS No. 1380359-84-1 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: Potent fluorescent PARP inhibitor; cell permeable
Alternative Names: AZD2281-BDY FL,Olaparib-BDY FL

Chemical Name: (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron

Purity: ≥90%

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Biological Activity

PARPi-FL is a fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.

Optical Data for PARPi-FL

Emission Color Green
λabs 502 nm
λem 510 nm

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Technical Data

M.Wt:
640.46
Formula:
C34H32BF3N6O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
1380359-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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