Paxilline

  ( 11 citations )    
Product Datasheet
Catalog Number:2006
Chemical Name:(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
Product Details
Citations (11)
Reviews
Biological Activity
Potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM).
Technical Data
  • M.Wt:
    435.56
  • Formula:
    C27H33NO4
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    57186-25-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Paxilline include:

11 Citations: Showing 1 - 10
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  1. Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction.
    Authors: Kim Et al.
    J Neurophysiol  2015;35:8245
  2. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.
    Authors: Hirono Et al.
    J Neurosci  2015;35:7082
  3. Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.
    Authors: Simkin Et al.
    J Neurosci  2015;35:13206
  4. Prostaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: a novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channels.
    Authors: Parajuli Et al.
    Eur J Pharmacol  2014;738:179
  5. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.
    Authors: Lai Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H1327
  6. Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different ages.
    Authors: Ksiazek Et al.
    Front Cell Neurosci  2013;7:185
  7. Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior.
    Authors: Montgomery Et al.
    Am J Physiol Cell Physiol  2013;304:C299
  8. Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice.
    Authors: Wan Et al.
    Nat Commun  2013;27:1859
  9. Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signaling.
    Authors: Bodhinathan Et al.
    J Neurophysiol  2010;104:2586
  10. Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.
    Authors: Gittis Et al.
    J Neurosci  2010;104:1625
  11. Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells.
    Authors: Pyott Et al.
    FASEB J  2004;24:9469
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