Paxilline

Tocris Bioscience | Catalog # 2006

SERCA ATPase blocker. Also potent BKCa channel blocker
Tocris Bioscience

Key Product Details

Description

SERCA ATPase blocker. Also potent BKCa channel blocker
View all Ca2+-ATPase Blockers »

Product Description

Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM).

Product Specifications for Paxilline

Molecular Weight

435.56

Formula

C27H33NO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one

CAS Number

57186-25-1

PubChem ID

105008

InChI Key

ACNHBCIZLNNLRS-UBGQALKQSA-N

SMILES

[H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.56 100

Preparing Stock Solutions for Paxilline

The following data is based on the product molecular weight 435.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.30 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.30 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.30 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 539 publications citing the usage of this product.

Product Documents for Paxilline

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Paxilline

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Paxilline (1)

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  • Paxilline as a selective potassium blocker worked ideally to block SK channels
    Name: Farzana Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/06/2018
    High-affinity and specific potassium channel blocker, used to study how it works to block SK (small conductance) channels. The product dissolved in DMSO and was excellent under lab conditions. Inhibition of SK channels were observed.
    Paxilline 2006

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