Chemical Name: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological ActivityPCI 29732 is a potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
Honigberg et al.
Active site profiling reveals coupling between domains in SRC-family kinases.
Krishnamurty et al.
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