PCI 29732

Key Product Details

Product Description

PCI 29732 is a potent BTK inhibitor (IC₅₀ = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20⁺ B cells.

Product Specifications for PCI 29732

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PCI 29732

The following data is based on the product molecular weight 371.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Krishnamurty Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 2013 PMID: 23143416
• Honigberg The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20615965

Product Documents for PCI 29732