Potent BTK inhibitor (IC50
= 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+
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All Tocris products are intended for laboratory research use only.
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
Honigberg et al.
Active site profiling reveals coupling between domains in SRC-family kinases.
Krishnamurty et al.