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PCNA I1

Catalog #: 5419 Datasheet / COA / SDS

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5419 has been discontinued.
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PCNA I1 | CAS No. 444930-42-1 | DNA, RNA and Protein Synthesis Inhibitors
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Description: PCNA inhibitor

Chemical Name: N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

Purity: ≥98%

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Biological Activity

PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

Technical Data

M.Wt:
310.37
Formula:
C17H14N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
444930-42-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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