Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd
= 0.41 μ
M), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2
M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro
values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.
Tan et al.
Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer.
Dillehay et al.
Mol.Cancer Ther., 2014;13:2817