Catalog Number: 5419
Chemical Name: N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
Biological Activity
Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.
Technical Data
  • M.Wt:
    310.37
  • Formula:
    C17H14N2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    444930-42-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.
    Tan et al.
    Mol.Pharmacol., 2012;81:811
  2. Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer.
    Dillehay et al.
    Mol.Cancer Ther., 2014;13:2817
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