PCNA I1

Tocris Bioscience | Catalog # 5419

PCNA inhibitor
Tocris Bioscience
Discontinued Product
5419 has been discontinued. View all DNA, RNA and Protein Synthesis Inhibitors products.

Key Product Details

Description

PCNA inhibitor
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

Product Specifications for PCNA I1

Molecular Weight

310.37

Formula

C17H14N2O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

CAS Number

444930-42-1

PubChem ID

5410824

InChI Key

WNYIQPCMVYAJLQ-JLHYYAGUSA-N

SMILES

O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.04 100

Preparing Stock Solutions for PCNA I1

The following data is based on the product molecular weight 310.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.11 mL 32.22 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PCNA I1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PCNA I1

For research use only

Customer Reviews for PCNA I1 (1)

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  • PCNAI1 quickly kills melanoma cells in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    PCNA I1 was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    PCNA I1 5419

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