hh PD 123319 ditrifluoroacetate (CAS 130663-39-7): R&D Systems
Catalog Number: 1361
Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Biological Activity
Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
Technical Data
  • M.Wt:
    736.67
  • Formula:
    C31H32N4O3.2CF3CO2H
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    130663-39-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa.
    Boulay et al.
    Mol.Pharmacol., 1992;41:809
  2. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
    Blankley et al.
    J.Med.Chem., 1991;34:3248
  3. Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.
    Tamura et al.
    J.Hypertens., 2000;18:1239
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 123319 ditrifluoroacetate include:

19 Citations: Showing 1 - 10
Filter your results:

  1. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.
    Authors: Gu Et al.
    J Immunol 2016;6:19840
  2. Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
    Authors: Raffai Et al.
    Journal of Vascular Research 2016;53:105
  3. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells.
    Authors: Fan Et al.
    Nat Commun 2015;8:2505
  4. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation.
    Authors: Chang Et al.
    Sci Rep 2015;6:5914
  5. The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder.
    Authors: Porter Et al.
    Eur Neuropsychopharmacol 2015;25:512
  6. The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function.
    Authors: Skorska Et al.
    J Cell Mol Med 2015;19:1975
  7. High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling.
    Authors: Santiago Et al.
    PLoS One 2014;9:e97281
  8. Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains.
    Authors: Speth Et al.
    PLoS One 2014;9:e105762
  9. Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression.
    Authors: Santollo Et al.
    Am J Physiol Regul Integr Comp Physiol 2014;307:R1396
  10. Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain.
    Authors: Speth Et al.
    Brain Res 2014;1583:132
  11. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
    Authors: Cruz Et al.
    PLoS Negl Trop Dis 2013;7:e2073
  12. Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain.
    Authors: Chakrabarty Et al.
    J Pain 2013;14:1053
  13. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
    Authors: Tsai Et al.
    Am J Physiol Heart Circ Physiol 2012;7:e33527
  14. Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.
    Authors: Hong and Garvin
    Diabetes 2012;60:765
  15. Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes.
    Authors: Santiago Et al.
    Cardiovasc Res 2011;89:139
  16. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium.
    Authors: Hasin Et al.
    Basic Res Cardiol 2011;106:175
  17. Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury.
    Authors: Curato Et al.
    PLoS One 2010;185:6286
  18. AT1 angiotensin II receptor and novel non-AT1, non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat.
    Authors: Bourassa Et al.
    Brain Res 2010;1359:98
  19. PPAR- γ inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1.
    Authors: Benkirane Et al.
    Hypertension 2006;290:H390
Expand to show all 19 Citations

Have you used PD 123319 ditrifluoroacetate?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information