PD 123319 ditrifluoroacetate

Tocris Bioscience | Catalog # 1361

Potent and selective non-peptide AT2 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective non-peptide AT2 antagonist
View all Angiotensin AT2 Receptor Antagonists »

Product Description

PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

Product Specifications for PD 123319 ditrifluoroacetate

Molecular Weight

736.67

Formula

C31H32N4O3.2CF3CO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6S)1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate

CAS Number

136676-91-0

PubChem ID

6604951

InChI Key

GPKQIEZLHVGJQH-ZXVJYWQYSA-N

SMILES

O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)N1[C@H]([C@](O)=O)CC(N(CC3=CC(C)=C(N(C)C)C=C3)C=N2)=C2C1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 51.06 100

Preparing Stock Solutions for PD 123319 ditrifluoroacetate

The following data is based on the product molecular weight 736.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.36 mL 6.79 mL 13.57 mL
5 mM 0.27 mL 1.36 mL 2.71 mL
10 mM 0.14 mL 0.68 mL 1.36 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

Calculators

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Product Documents for PD 123319 ditrifluoroacetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 123319 ditrifluoroacetate

For research use only

Citations for PD 123319 ditrifluoroacetate

Customer Reviews for PD 123319 ditrifluoroacetate (1)

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  • Selective angiotensin receptor type 1 and 2 blocker PD123319 and EMD66684
    Name: Hitesh Soni
    Species: Piglet
    Assay Type: In Vitro
    Cell Line/Tissue: primary kidney mesangial cells
    Verified Customer | Posted 01/04/2018
    We have also used Tocris another product EMD66684 (angiotensin receptor type 2 blocker) and published results in EXPERIMENTAL CELL RESEARCH 324(2014)92 – 104.
    To inhibit angiotensin II receptor type1 in neonatal pig glomerular mesangial cells (primary culture) to study proliferation of mesangial cells and calcium imaging studies.
    PD 123319 ditrifluoroacetate 1361

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