Catalog Number: 1361
Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Biological Activity
Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa.
    Boulay et al.
    Mol.Pharmacol., 1992;41:809
  2. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.
    Blankley et al.
    J.Med.Chem., 1991;34:3248
  3. Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats.
    Tamura et al.
    J.Hypertens., 2000;18:1239

The citations listed below are publications that use Tocris products. Selected citations for PD 123319 ditrifluoroacetate include:

Showing Results 1 - 10 of 18

  1. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.
    Authors: Gu Et al.
    J Immunol
  2. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells.
    Authors: Fan Et al.
    Nat Commun
  3. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation.
    Authors: Chang Et al.
    Sci Rep
  4. The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder.
    Authors: Porter Et al.
    Eur Neuropsychopharmacol
  5. The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function.
    Authors: Skorska Et al.
    J Cell Mol Med
  6. High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling.
    Authors: Santiago Et al.
    PLoS One
  7. Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains.
    Authors: Speth Et al.
    PLoS One
  8. Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression.
    Authors: Santollo Et al.
    Am J Physiol Regul Integr Comp Physiol
  9. Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain.
    Authors: Speth Et al.
    Brain Res
  10. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
    Authors: Cruz Et al.
    PLoS Negl Trop Dis
  11. Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain.
    Authors: Chakrabarty Et al.
    J Pain
  12. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
    Authors: Tsai Et al.
    Am J Physiol Heart Circ Physiol
  13. Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.
    Authors: Hong and Garvin
  14. Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes.
    Authors: Santiago Et al.
    Cardiovasc Res
  15. Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium.
    Authors: Hasin Et al.
    Basic Res Cardiol
  16. Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury.
    Authors: Curato Et al.
    PLoS One
  17. AT1 angiotensin II receptor and novel non-AT1, non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat.
    Authors: Bourassa Et al.
    Brain Res
  18. PPAR- γ inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1.
    Authors: Benkirane Et al.
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