(+)-PD 128907 hydrochloride
Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Biological Activity(+)-PD 128907 hydrochloride is a high affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat.
Bristow et al.
Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907.
Pugsley et al.
Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907.
Witkin et al.
Citations for (+)-PD 128907 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:
9 Citations: Showing 1 - 9
Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction.
Authors: Shin Et al.
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease.
Authors: Cote and Kuzhikandathil
J Neurosci 2015;585:33
First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
Authors: Schulz Et al.
Br J Pharmacol 2012;167:1480
Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.
Authors: Marcellino Et al.
Neurosci Lett 2008;283:26016
Regulation of DA transporter function and cell surface expression by D3 DA receptors.
Authors: Zapata Et al.
J Biol Chem 2007;282:35842
Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
Authors: Basso Et al.
Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the DA D1 and D3 receptors.
Authors: Zhang Et al.
J Neurosci 2004;24:3344
Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.
Authors: Clemens and Hochman
J Neurosci 2004;24:11337
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