PD 158780

( 1 Review )    
Product Datasheet
Catalog Number:2615
Chemical Name:N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
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Biological Activity
Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
Technical Data
  • M.Wt:
    330.18
  • Formula:
    C14H12BrN5
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    171179-06-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Average Rating: 4 (Based on 1 review)

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Species Mouse

Other Experimental Details

Other Experimental Details Coating our tubing with BSA helped to prevent the staining that occurred with this compound.

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