PD 158780

Catalog # Availability Size / Price Qty
2615/10
2615/50
PD 158780 | CAS No. 171179-06-9 | EGF Receptor Inhibitors
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Description: Potent ErbB receptor family inhibitor

Chemical Name: N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Technical Data

M.Wt:
330.18
Formula:
C14H12BrN5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
171179-06-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for PD 158780

The citations listed below are publications that use Tocris products. Selected citations for PD 158780 include:

2 Citations: Showing 1 - 2

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Bath application in whole cell recording
By Anonymous on 12/11/2017
Species: Mouse

Electrophysiology whole cell recordings and it worked as expected.

Coating our tubing with BSA helped to prevent the staining that occurred with this compound.


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