PD 158780

Tocris Bioscience | Catalog # 2615

Potent ErbB receptor family inhibitor
Tocris Bioscience

Key Product Details

Description

Potent ErbB receptor family inhibitor
View all EGF Receptor Inhibitors »

Product Description

PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Product Specifications for PD 158780

Molecular Weight

330.18

Formula

C14H12BrN5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

CAS Number

171179-06-9

PubChem ID

4707

InChI Key

KFHMLBXBRCITHF-UHFFFAOYSA-N

SMILES

CNC1=NC=C2N=CN=C(NC3=CC=CC(Br)=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.01 100
Ethanol 8.25 25

Preparing Stock Solutions for PD 158780

The following data is based on the product molecular weight 330.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.29 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.30 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for PD 158780

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 158780

For research use only

Customer Reviews for PD 158780 (1)

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  • Bath application in whole cell recording
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 12/11/2017
    Coating our tubing with BSA helped to prevent the staining that occurred with this compound.
    Electrophysiology whole cell recordings and it worked as expected.

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