Catalog Number: 2520
Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Biological Activity
Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
    Peterson et al.
    Circulation, 2001;103:2303
  2. Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload.
    Chancey et al.
    Circulation, 2002;105:1983
  3. Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors.
    O'Brien et al.
    J.Med.Chem., 2000;43:156
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