Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50
values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
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Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
Peterson et al.
Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload.
Chancey et al.
Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors.
O'Brien et al.