Chemical Name: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Biological ActivityBroad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors.
O'Brien et al.
Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
Peterson et al.
Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload.
Chancey et al.
Citation for PD 166793
The citations listed below are publications that use Tocris products. Selected citations for PD 166793 include:
1 Citation: Showing 1 - 1
Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.
Authors: Bencsik Et al.
Front Pharmacol 2018;9:296
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